Antibiotic resistance of strains of Shigella spp. Causing travelers' diarrhea: a retrospective analysis from 1995 to 2010

The objective of the study, carried out in Spain, was to assess the resistance to antibiotics of strains of Shigella spp. Isolated from patients with travelers' diarrhea returning from tropical regions of the world, 1995 to 2010.

A total of 191 Shigella spp strains were tested during the study.

In general, in recent years, the incidence of travelers' diarrhea caused by shigella has decreased. At the same time, a high level of resistance of Shigella isolates was noted for a number of antibiotics, in particular tetracycline (84%), cotrimoxazole (75.5%), ampicillin (45.5%). A low resistance level was established for ciprofloxacin (2.1%), azithromycin (3.9%) and furazolidone (8.4%).

When analyzing the dynamic data, it should be noted that for the period 1995-2000. at 2001-2010 the level of resistance to ampicillin (62.5% vs 28.4%, respectively), to amoxicillin / clavulanic acid (19.8% vs6.6%, decreased statistically significantly respectively) and chloramphenicol (23.4% vs 10.4%, respectively), however, resistance to nalidixic acid and tetracycline has increased over time.

Thus, this retrospective study, on the one hand, showed a decrease in the frequency of release of Shigella during travelers' diarrhea, and on the other hand, it revealed significant differences in the level of antibiotic resistance of Shigella spp isolates isolated. various antimicrobial agents.